NAD VS. NADH:
The Definitive Difference

WHICH HOLDS ESSENTIAL BENEFITS FOR YOUR HEALTH?

The amazing science behind NAD is fueling one of the hottest science stories emerging today, for a very good reason. Originally derived from extensively researched cellular health technology, there are now thousands of Americans embarking on a journey of revitalization, health, and longevity, all thanks to the benefits of increased NAD levels. Promoting increased NAD levels can result in a wide array of benefits that cover many aspects of human health that can be affected by aging. Growing old is a requirement, but science has finally given us the freedom to see age as just a number. For most of us, mental focus, cardiovascular health, cellular functionality, metabolism, and energy levels can be negatively affected by aging, until now. What if you could feel young again?. Harvard Medical, Stanford University School of Medicine, and Weill Cornell Medicine studies concluded that increases in NAD resulted in cells behaving younger and more vibrant! These amazing benefits are now possible through proven science that points to the significance that NAD has in our lives. NAD does hold real benefits and can finally be supplemented exclusively via nicotinamide riboside.

BUT HOW DOES NAD HELP US FEEL YOUNG?

To understand NAD, we need to take a look at one of the most important processes for producing energy that occurs in the human body. I’m talking about the Krebs cycle. This cycle is composed of a series of complex chemical reactions that takes place within the mitochondria - the powerhouse inside every single cell in the body. The Krebs cycle produces energy that is absolutely essential to cellular function. So what does NAD have to do with all of this? Well, the science clearly points to NAD as a necessary player in the Krebs cycle. So if you want to promote increased energy levels, healthy cellular function, and all the entailed benefits, you need to increase NAD levels.

But if you do any type of research into NAD, you may come across two results on Google, NADH and NAD +. Leaving you wondering, which can bring you the most essential benefits to your health? Well, that’s why I’m here to set the record straight.

In the various steps of the Krebs cycle, scientists have observed that NAD+ is in fact required in 3 key steps that work towards producing energy. This is because NAD + holds a positive charge which allows it to carry electronsNAD+, eventually leading to energy production.

As for NADH, it turns out that in the same 3 steps of the Krebs cycle, it appears as a byproduct of chemical reactions and holds a neutral charge. Meaning the body has no problem producing NADH because it is produced as a result of these reactions and therefore there is no need to supplement it. On the other hand, boosting NAD + levels promotes optimized energy production and mitochondrial genesis because NAD + plays a key role in setting these chemical reactions into motion. Meanwhile, NADH is not useless, but boosting NADH is not necessary.

SO YOU MAY BE WONDERING,
WHY DOES NADH COME UP WHEN SEARCHING FOR NAD+?

The truth is that NADH is a reduced form of NAD+, and there are various factors that make NADH much less efficient than taking supplements that directly boost NAD + levels in your body, like nicotinamide riboside. In fact, even relative to the dosage, supplements that increase NADH are marked up at a higher cost for a less effective product when compared to NAD + boosters. For the most part, NADH boosting is used anecdotally for mental alertness and not primarily for optimizing cellular function like NAD + boosters; even though NAD + is currently being researched for Alzheimer’s treatment *.

However, extensive research into anti-aging has revealed that NAD + levels can drop by as much as 50% as we age. This highlights the real value in increasing NAD + levels through nicotinamide riboside and ensuring that the body continues to produce optimal energy levels in order to retain vitality and longevity. That is why Dr. David Sinclair’s Harvard Medical study concluded that introducing NAD + to the cell resulted in the “equivalent of a human 60 year old becoming more like a 20 year old”, claiming “we went straight back to being young again”!

SO LET’S TAKE A LOOK AT A FINAL BREAKDOWN
OF THE BENEFITS OF NAD+ COMPARED TO THOSE OF NADH:

    Clinical Benefits of NAD+ :

  • Optimized Mitochondrial Function1
  • Improve Metabolism2
  • Cardiovascular Health3
  • Mental Clarity and Focus4
  • Heightened Energy Level5

    Clinical Benefits of NADH:

  • Only Use Anecdotally
  • Trials Actually Showed Insufficient Evidence for Benefits for Memory, Energy, or Fatigue6
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REFERENCES:
  1. J Biol Chem. 2002 May 24;277(21):18881-90. Epub 2002 Mar 7. (click here)
  2. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. (click here)
  3. Br J Nutr. 1991 Mar;65(2):285-99. (click here)
  4. J Neurosci. 2006 Aug 16;26(33):8484-91 (click here)
  5. Cell Metab. 2015 Jul 7;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023. (click here)
  6. J Neural Transm (Vienna). 2000;107(12):1475-81(click here)