How NAD+ is changing
the way we see aging

If you would like to know how a small group of Doctors and Scientist defied the laws of Aging and then figured a way to make it available to you, me, and the rest of the general public, then this is going to be the most interesting message you will ever read.

There’s a group of Bio-Geneticist based out of Southern California who have taken the initiative to patent and produce what a Harvard Scientist calls “Essential to Life” and may very well be the next step in human evolution. And this is no ordinary Scientist. This is Dr. David Sinclair, Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Sinclair is considered one of TIMES Magazine “Most Influential People in the World”.

Dr. Sinclair, an expert in human genetics and cellular function, discovered a link to aging and degenerative disease and the secret weapon to reversing it. He and his team took a closer look into our cells and determined that as we age, our cells become less and less efficient due to the lack of a very important and essential metabolite called NAD+. Low levels of NAD+ cause you to feel less energized, less focused, excess mental fog and mental loss, excess weight gain especially in your mid section and other issues and illnesses related to aging. This is commonly known as mitochondrial dysfunction.


NAD+ is an important metabolite found in all human cells that has recently shown to restore mitochondria functionality and vitality1. “NAD+ levels tend to drop by as much as 50% as we get older”, according to Dr. David Agus a world leading Physician in Cancer treatment and a pioneer in Biomedical Research. Above all, NAD+ cannot be taken like other vitamins because it does not survive the digestive system long enough to enter your cells, making it extremely difficult to supplement your NAD+ levels.

Sinclair concluded that higher NAD+ levels promote cells to behave younger and more vibrant. Studies show that high levels of NAD+ result in stronger, healthier cells and mitochondrial function. In fact, one study resulted in Sinclair publishing a ground-breaking paper which found that introducing NAD+ to the cell resulted in the “equivalent of a human 60 year old becoming more like a 20 year old”, claiming “we went straight back to being young again”2. More importantly, their analysis revealed that in its initial stages, mitochondrial dysfunction is reversible with NAD+ supplementation, enabling the life and health of cells to be prolonged  at the molecular level.

Now imagine feeling like you’re 30 again and having the energy to go out and meet new people, having the strength to exercise and look great every single day. Imagine if the cells in your brain were restored to regain their cognitive abilities or if the cells in your eyes performed like never before, to even restoring the cells in your skin and muscles to appear and perform like they did in their youth. All these amazing benefits may now be available to you.

According to Dr. David Sinclair of Harvard University, Dr. Anthony Sauvé of Cornell University, and thousands of other physicians, including myself belief you can do this by restoring your NAD+ levels. “If we could restore lost NAD+, aging cells might behave as if they were younger. Immortality is out of reach but living more years with a body that’s robust enough to make the most of them is a real possibility” says Dr. David Agus.

In fact, there’s an extensive amount of research to back up this claim.

My name is Dr. David Leonardi MD. I am a diplomat for the American Board of Anti-Aging Medicine, a certified Nutrition Specialist by the American College of Nutrition, and a Professional member of the American Diabetes Association. I graduated from the University of Miami School of Medicine and received my residency in emergency medicine at the University of California, San Francisco. I have been practicing the science of vitality and longevity medicine exclusively for 20 years now and just about every day I get the same question from many of my new patients; why do I feel so old?


Mitochondria has been determined to play one of the most important roles. Mitochondria are specialized organelles found in your cells, which perform important functions related to converting nutrients such as fats, proteins, and carbohydrates into energy. They are responsible for your cellular respiration and make up about 10% of your body weight. About 70% of the energy you produce goes to keeping your organs running in the background; like your heart and lungs. So in other words, your Mitochondria produce the energy that keeps you alive.

Researchers warn that unhealthy mitochondrial may lead to an array of degenerative illnesses, ranging from diabetes and neurological disorders to heart failure . Mitochondria undergo a complex series of biochemical transformations that generate energy. This energy-intensive process results in a constant exposure to free radicals—and rendering the mitochondria especially vulnerable to oxidative damage. The result is a cellular breakdown: the mitochondria gradually deteriorate, leading to a decrease in vital energy production and a deadly increase in free radical generation.

Over time, this continuous free-radical onslaught destroys the mitochondria through progressive membrane damage and molecular decay. As levels of oxidative damage from mitochondrial dysfunction steadily rise, the body’s antioxidant defenses gradually weaken at the same time, accelerating cellular dysfunction and death. This fatal cycle speeds the general decline in overall body function and contributes to the beginning of degenerative disease.

Weight Gain:

Researchers have also reported that inefficient mitochondria increase your chances of reaching obesity, the disease brought and perpetuated by the vicious cycle of excess weight and body fat gain. Because your mitochondria are responsible for metabolizing nutrients like carbs and fat, disruptions can trigger your body into fat storage mode. This is why weight is such an issue amongst older individuals and why weight loss seems almost impossible.

Recent studies have demonstrated that healthy Mitochondria play a broader role in protecting us against a wide range of adverse health conditions. When our mitochondria function correctly there is a reduced risk for the development and spread of certain illnesses within our cells and within our bodies.

According to Dr. Anthony Sauvé, “Mitochondrial decline is the hallmark of many diseases associated with aging, such as cancer and neuro-degeneration”. In addition, a recent study conducted by the American Geriatrics Society showed that more than “40% of adults 60 years of age and older have a combination of risk factors known as metabolic syndrome, which puts people at increased risk for developing diabetes, cardiovascular disease, and even certain cancers"3.

A 2010 study determined nearly 40 percent of men and women born today will be diagnosed with cancer at some time during their lifetime. Considering that cancer is sometimes referred to as Mitochondrial Disease, cellular health has now become the most important factor to consider by many physicians.


NIAGEN® is a proprietary ingredient also known as Nicotinamide Riboside or NR for short. NIAGEN® is the only proven metabolite shown to boost NAD+ levels and the best part it’s a naturally occurring vitamin B3, so it is completely safe4. Unlike standalone NAD+, NIAGEN® can be ingested orally. It enters your body to be converted into NAD+ surviving your digestive system. NIAGEN® has been proven to elevate NAD+ levels within 8 hours of ingestion providing a surge of energy and noticable mental clarity5.

What is Nicotinamide Riboside?

Nicotinamide Riboside is a pyridine-nucleoside form of vitamin B3 that functions as a precusor to nicotinamide adenine dinucleotide or NAD+. Nicotinamide Riboside is naturally found in food, such as milk but the body does not get enough of it, especially as we age and NAD+ levels naturally decline.

A 2015 study showed a single 100mg dose of Nicotinamide Riboside was effective in raising NAD+ levels by 30%; 300mg and 1000mg dosages showed a 50% increase in NAD+ levels. The increase in NAD+ levels were longer lasting at the higher dosages. NIAGEN® is the only proven dietary supplement shown to elevate NAD+ levels making the most reviewed and essential supplement on the market today.

The benefits of restoring NAD+ levels are:

  • Optimized Mitochondrial Function1
  • Improve Metabolism6
  • Cardiovascular Health7
  • Mental Clarity and Focus8
  • Heightened Energy Level9

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  1. J Biol Chem. 2002 May 24;277(21):18881-90. Epub 2002 Mar 7 (view study)
  2. Reversing Aging: Not as Crazy as You Think. TIME, 2013 Dec 19 (view article)
  3. Nitric Oxide and Mitochondrial Biogenesis. Journal of Cell Science, 2006 May (view study)
  4. Niagen Nicotinamide Riboside New NDI Status from FDA (view page)
  5. Dose-Dependent Elevation of the Blood NAD+ Metabolome by NR (view results)
  6. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022(click to download)
  7. Br J Nutr. 1991 Mar;65(2):285-99 (click to download)
  8. J Neurosci. 2006 Aug 16;26(33):8484-91 (click to download)
  9. Cell Metab. 2015 Jul 7;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023 (click to download)